Influence of chemistry and fiber diameter of electrospun PLA, PCL and their blend membranes, intended as cell supports, on their biological behavior

نویسندگان

چکیده

The prevalence of osteoarthritis, a degenerative cartilage disease that causes joint surface erosion and loss mobility, emphasizes the need producing functional articular replacement. Tissue engineering has been focus recent research as possible strategy for regeneration repair. most widely used technique manufacture nanofibers is polymer electrospinning. Polylactic acid (PLA) polycaprolactone (PCL) have proved particularly suitable nanofiber preparation, with many biomedical applications. main aim this work was to evaluate behavior adipose tissue-derived mesenchymal stem cells (ASCs) cultured on biomaterials PLA, PCL combination both (PLA/PCL), manufactured by We analyzed bioactive properties these in cultures them, terms proliferation, adhesion, morphology, viability differentiation. In addition, influence thickness fibers each biomaterial cellular characteristics evaluated their use Cartilage Regenerative Medicine applications promote chondrogenic Depending parameter assessed, different results were obtained biomaterial. Using polymers successful obtained, although case response all experiments significantly better. As blends, positive outcomes but they did not overtake PCL. Interestingly, ASCs able differentiate into chondrocytes without adding specific media three tested. Moreover, marked cell differentiation 1.8 μm-fiber diameter PLA/PCL blends observed. These findings may play key role Engineering.

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ژورنال

عنوان ژورنال: Polymer Testing

سال: 2021

ISSN: ['1873-2348', '0142-9418']

DOI: https://doi.org/10.1016/j.polymertesting.2021.107364